Density altitude only changes about 5000 ft through the day.... and depending on how long you are in line it could screw your tune unless you guess well. Oh, unless you are blown alcohol and then you can run a little rich and be ok... We ran an AEM by cylinder data system on Max's Liner (blown alcohol mechanical injection) one year... the data kept telling us it was lean... the drag racer influencing Max's tuning decisions said it was rich... the hole in the piston told us never listen to drag racers at Bonneville....
So an aftermarket EFI, MOTEC, FAST, AEM and a variety of others can tune by cylinder, update on the go to compensate for manifold ram air pressure and make your tune whatever you pick. Leaded fuel will not kill your O2 sensor in several years of racing.... ours has survived 5 years, start with a really good lab grade Bosch sensor... you can limit it's adjustment range should it decide to die suddenly from lead poisoning. You can use EGT and O2 in each cylinder to influence your tuning decisions to ensure you are getting all you can from your motor...
We used to be carb guys, used weather station to pic jets 5 back in line... thrashed to get them in the 4 carbs and driver in on time... Now we use the MOTEC, get our coaching from Dave Dahlgren at Engine Management Systems, he can set you up from start to finish. Appropriately for the Voodoo of EFI, he is located in Mystic CN...