My guess is that whatever is going to happen will probably occur within those first 1000 cycles.
Regards, Neil Tucson, AZ
I'm not sure about this. If our average run time is 3 minutes at 8000 RPM, we have just subjected our fasteners to 24,000 cycles. I would feel better if tests were performed for a much higher number of cycles. Of course, metals have fatigue limits and I imagine materials like Loctite do too.
That is because drill bits can't drill in at an angle, should snap the little ones in no time... that's why they sell the little ones in 10 packs 
if you can mill a small flat, it will drill a lot better... in a pinch drill in straight a little, then change your angle, drill a little more, then change your angle, you get the picture until you are drilling the direction you want to drill for the hole.
Buy a 10 pack of 1/16ths 
This and the post by Peter Jack, of course, are the way most of us learned to corner drill nuts. Lots of bits and patience are required as well as extra nuts because of the ones we ruined, some with part of the drill bit still in the hole.
A few places like Aircraft Spruce sell a fixture that will allow you to drill the hex bolt corners without breaking those small drills. It is essentially a drill guide. Cobalt drills are good for drilling Grade 8 bolts for safety wire.
Regards, Neil Tucson, AZ
My fixture definitely didn't come from Aircraft Spruce, more likely, gangman industries! The included angle for the nut to rest in isn't even correct, so the nut does not make intimate contact with the jig allowing the bit to bend. Breaks the bit every time.
I also use the 3/32" bit with .032 inch wire.
it would be easier to use the flat star washers with the safety wire tab on them.
the tab is positioned to pull the nut or bolt in the right direction.
there are about 3 tabs that fold up onto the flat of the nut or bolt.--
1 tab is all that's needed to hold.
Bf
I have tried the star washers, but the ones I've seen are too flimsy to prevent a grade 8 nut from backing out. I don't think they would be acceptable for fork nuts, for example. Also, the 3/32" bit is more than double the strength of the 1/16", so is easier to use without breaking it. I wouldn't use the 3/32" on smaller nuts because of possible weakening of the nut.
I found these on Ebay:http://www.ebay.com/itm/150352899620?ssPageName=STRK:MEWAX:IT&_trksid=p3984.m1423.l2649
Anybody out there want to buy about 80 of them? Good buy -- cheaper than drill bits!
Tom