I guess I'm fortunate in that the windows on the Midget are essentially flat - for me, it's doable, but certainly not desirable, and I suspect it could be less safe than safety glass.
On a production car with no frame or channel on the top or back of the side windows, I could easily see where Lexan would flex out at speed - it's just not as rigid as safety glass. That in itself could cause a safety problem - it could actually compromise the drivers operating environment. One could forsee a situation where the window might be sucked out far enough on the back edge or the top to pull it out of the top of the front channel, moving it farther into the windstream and creating a cockpit hazard.
I'm certain there are a lot of other cars - primarily production cars - on which the door window frame design would be incompatible with a more flexible replacement.
I'll do what I can to to make it legal, but if doing so actually makes my car less safe, then I'm going to have to rethink as to whether or not I'm willing to race. It would be unwise to make a safety modification to a car that could, in fact, make it less safe.