It is a good idea to select a fuel supplier that has a racing program with helpful and intelligent tech support. They can help you to select a good base fuel for your program. Then, stay with that fuel during your development and racing. Experience has shown me that the types of refinement you are doing are somewhat dependent on the characteristics of the fuel. Switching fuels during the development process can invalidate a lot of the results and especially the spark advance curve.
As an example, my preference is gasolines that burn quickly and this allows me to use less spark advance. The timing settings are a bit retarded for heavier fuels and I cannot get the high end power they provide. I do not have enough spark advance when I use my curves developed for lighter fuels.