In a word, YES.
The real point of fact is: How much of a restriction? The ONLY way to know for sure is to flow bench test the combo, both ways, back to back. Manifolds ALWAYS add SOME restriction. Manifolds with turns, add more. A gentle/gradual turn will add less restriction than a tight/sharp turn. How much might be tolerable would need to based on the "flow demand" that the engine requires for the bhp desired. AND, more importantly, ANY turn messes with the "wet flow" of the fuel you are using. Since fuel is heavier than air, it will turn "poorly".
Not trying to discourage you, just want you to put some thought into what you are going to do. Take a look a some of the airflow numbers I've posted on Milwaukee Midget's Build Diary, pages 230-245 approx.
Also read:
A/ any book on Fluid Dynamics
2/ Engine Airflow by Harold Bettes
d/ How to Port & Flow Test Cylinder Heads by David Vizard
AND, Most Importantly: Generate and believe your own data. Don't listen blindly to some "expert" or "guru", regardless of how much "experience" they have. Part of this journey is developing your own cerebrum.
Fordboy