As for the local hotels, I would recommend the Hampton Inn first, the Holiday Inn second and the Comfort Inn third. Quality falls off real quick after that. You do want to lock up everything and prepare for the worst, the area around the hotels is pretty seedy. This is the first Hampton where I have ever seen a security guard patrolling the parking lot.
By all means avoid the Drury Inn in Hayti, I nearly had a divorce on my hands after booking that two years ago. I was happy to break my bike the first day and go home, anything would have been better than taking my wife back there.
Dining choices are weak in Blytheville, my breakfast at the Hampton is still my best meal there so far. I know we don't go for the food, but it is never a good idea to torture your pit crew. The local food in Wilmington, Loring, and Wendover are much better.