If you are going after a 250 production record I would use the Kawasaki 250 KR-1S (same as in my piccy) as off the shelf it is the best package. I ran a best of 137mph (136.5mph two way average) on mine in 2007and I think it has potential to go over 140mph; I didn't have the correct gearing .
There are a few in the states but of all the two strokes these, in the US, are probably the rarest.
If you can find one the KR-1R is the daddy however not sure they ever made 500 of them.
Of the other two strokes all are held back by the expansions. On the KR-1S Kawasaki did such a good job with the expansion no aftermarket pipe could beat the stock pipe. Not the case with all the other 250 strokers where to get the best out of them you need to fit after market kit.
The Suzuki RGV VJ22 and VJ21 are held back by the design of the expansions and to a lesser extent so is the Aprilia RS250 (same engine as the RGV250).
The Suzuki RGV VJ23 is probably a better bet - Japanese models were restricted to 45hp (as were most 250 and 400cc machines) but a full power version was exported again it is the standard expansions that limit them.
The Yamaha 3XV which is basically a TZ250 is the best of the Yams but again the standard exhausts hold it back.
The Honda NSR250 MC28 or 21 are the best Hondas to go for but again I think the stock expansions limit them.
The four stroke 250's will never match the two strokes, they are down on power, heavier and have a larger frontal area.
Info on the RGV
http://www.rgv250.co.uk/Info on the NSR
http://www.nsr-world.com/