I've been flogging the methanol/supercharger dead horse combo for 5 years now Jim, & I'm "nearly there"
Maj is right, EFI is the way to go, but, if you're as stubborn as I, you will sort carbs out, eventually, although my setup is draw thru, the a/f needs are the same as blow thru.
Start with at least +2.2 times more fuel than you would need with gas,,,+ 2.5 is safer, this includes ALL jets, not just the main jets, make sure the needle jets are at least .001" larger than your mains.( there's quite a bit of math involved in calculating needle / needle jet sizes)
Remember,,a methanol engine that runs fine during test runs will run the risk of lean out as the cylinder head temp increases, and excessive heat & lean mixture = detonation,(I hope you have good piston stocks)
Heat is forced inducted engine's enemy, intercooling makes sense to overcome that, but with that (& carbs) methanol tends to drop out of suspension,
O2 sensors don't like methanol either (unless you use expensive ones) & tend to tell lies until you get the mixture "right"
A byproduct of methanol burning, is water, especially on initial start up, water kills O2 sensors.
Plug reading is the best way to find out why your engine died, not if it will die,,as is egt reading, but it all helps to get you there.
Enjoy,,,,,,
Tiny