This might help. It is experience from the 1970's when we were trying to build British vertical twins capable of racing against Japanese four cylinder bikes. The weaknesses of the brit bikes were poor machining for the most part, weak metal, and designs that were originally done before World War II. The engines were naturally aspirated and running on gas. The failures were like engines using fuel, i.e. cylinders pulling away from the blocks, cylinders breaking at the base flanges, rod big end bearings flattening, etc.
This is what I learned. The combustion process produces a peak pressure a short time after ignition and this is not proportional to rpm. The pressure spike, if it happens when the piston is too close to top dead center, pushes down on the piston when the rod has poor leverage on the crank. This is hard on the rod bearings, everything else, and it hurts power. The pressure spike itself, if it happens when the piston is too far down from TDC, is not as great as it can be - although the rod to crank leverage is better. The pressure spike and piston position need to be optimal for the most power and engine life. Spark advance timing can be used to keep the pressure spike and piston position optimal, to some extent. So can choice of fuel. The other factor is engine speed. The piston is further past TDC when the pressure spike occurs at higher rpm.
One of my engines was built at the limit in regards to compression and the anti-knock capabilities of the gasoline I had. The pressure spike and optimal piston position were within tolerable limits for a few thousand rpm. My method was to roll on the throttle until the engine was within those rpm limits and then to open it up all of the way. That is the only way I could get the engine to be powerful and reliable.
This is a long story. The point is, it helps me a lot to be aware of what happens in the combustion cycle and when it occurs. Some of this might apply to fuel use.