One of the biggest problem that we experienced with running very large injectors is that there is a minimum turn on time. For most injectors, it is about 1.2ms. When you are pulling really great vacuum as we do with our turbo engine the turn on time was about 1.25ms. As you can imagine, .05 of actual time was pretty dependent on battery voltage would determine if the injector would even turn on enought to flow anything. This was much more an issue with the Electromotive when we were trying to run in the semi sequential mode as we were injecting on every stroke.
Anyhow, with Electromotive stuff, it's okay to go a little big but don't get carried away.
Rob, if you step up to a system that lets you tailor the opening time - tuning oversized injectors becomes much easier.
Motec, Megasquirt are a couple examples that will let you tune PWM time threshold and opening time versus voltage. FAST, Electromotive - not so much. I tune a 1000hp, 170 cubic inch SVO Ford engine that's street driven, running 160 lb/hr injectors and it idles at mid 14s on the wideband, at 750rpm. With his previous bigstuff3, it would idle 10:1 AFRs unless you idled it at 2000rpm.